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APA
Stokely, A (n.d.). Neuronal Pyrophosphatase Catalyzed Entanglement of Phosphate Ions in Posner Molecules .
MLA
Stokely, AndyNeuronal Pyrophosphatase Catalyzed Entanglement of Phosphate Ions in Posner Molecules . , n.d.
Chicago
Stokely, AndyNeuronal Pyrophosphatase Catalyzed Entanglement of Phosphate Ions in Posner Molecules . , n.d.
Turabian
Stokely, AndyNeuronal Pyrophosphatase Catalyzed Entanglement of Phosphate Ions in Posner Molecules . , n.d.
Description / Abstract
A recently developed quantum mechanical model of cognition theorizes that neuronal signaling is significantly influenced by entangled Posner molecules (Ca9(PO4)6) in the brain. According to this model, entangled Posner molecules form upon the inorganic pyrophosphatase-mediated hydrolysis of singlet pyrophosphate, which produces two entangled phosphates. These entangled phosphates then coordinate with surrounding Ca2+ and other entangled phosphate molecules to form the S6 symmetric Posner molecule, which is presumed to serve as a qubit for neuronal signaling. This theory assumes that the hydrolysis of pyrophosphate significantly favors singlet pyrophosphate due to its ability to freely rotate while in the binding pocket of pyrophosphatase. However, to our knowledge, this assumption has never been tested. Using molecular dynamics, we were able to conclude that singlet pyrophosphate does not rotate within a timescale of 1 μs while present in the pocket of pyrophosphatase. These results call into question the role of nuclear spin in the specificity of the pyrophosphatase-mediated hydrolysis of pyrophosphate.
Arete: The PLNU Honors Journal
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Keywordsmolecular dynamics, computational chemistry, quantum mechanics, neuroscience, biochemistry, and theoretical physics, Arete the PLNU Honors Journal
Degree AwardedB.S. in Biology-Chemistry
Awarding InstitutionPoint Loma Nazarene University
Committee MembersAriane Jansma, Heidi Doss, and Breeann Kirby
Supervisor or ChairLane Votapka
Peer Reviewed?No
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PLNU Undergraduate Honors Projects 2016-2020
81 Resources
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